I have been involved with trying to reduce vibration on british vertical twins years ago which are just like a big single. You cannot balance them but you can change the balance factor to change the planes of vibration. It is a complicated subject but basically you take 100% of the big end weight of the rod and then take the weight of the small end of the rod plus the piston, rings, clips and wristpin. and multiply that by the balance factor. what will give you the weight to place on the crankpin and it should be equidistant from the center of the crankpin not hanging off one side. A 50 percent balance factor basically spreads the vibration evenly in the horizontal and vertical planes where the vibration is the strongest. You will read a lot about balancing for a certain RPM but when you understand that the out of balance forces increase with the square of rpm. So the faster you turn the engine the stronger the forces. There are two types of out of balance on our little engines reciprocating, and rotational. (also a small amount of rocking couple. The rotational and rocking couple can be balanced out just fine reciprocating cannot. This is where the balance factor comes in. changing the balance factors higher or lower than 50 percent increases vibrations in one plane and reduces it in the other. British bikes use factors between 60 and 80 percent usually opting for more vibration in the horizontal plane. The reason people thing you can balance for a particular rpm has to do with resonant frequency. When our motor is mounted in a frame the whole thing will have a resonant frequency that when vibrated at that frequency can multiply the feeling of vibration by a large factor which is perceived as a bad vibration but by changing the balance factor and moving the vector of the major vibration force may change or eliminate reaching the resonant frequency of the vehicle. When you bring your predator to a shop and say balance it to reduce vibration at x rpm they can't really do that not knowing what the resonant frequency of you project is. Manufacturers of motorcycles have the facilities to test that and balance around that. That is why when Norton went from the roadholder frame which mounted the motor rigidly had a balance factor from 70 to 84 percent to the commando which had a rubber bushing to allow the motor to vibrate freely they went to a 52% balance factor.
So what I found out during all my british (BSA) flattrack days was to minimize vibration by selecting the lightest reciprocating parts I could find, which basically was the lightest piston and wristpin.
So when guys change the rod and piston it may change the way it vibrates if the parts are heavier or lighter but I doubt that you would notice much unless it was a LOT heavier.