Find something that stays flexible. Stuff in a tube called The Welder is good. As mentioned above, Goop is good. Shoe goop, window goop, aquarium goop...they all stick like crazy and they stay flexible.
I asked you before, Is it a split rim? Is there rust inside the rim, touching the tube?
If so, you need to clean ALL of that rust out, get the wheel smooth, paint it, and make sure no more water gets in there.
Sorry, forgot to ask if it is steel or aluminum. I assumed steel, because of the symptom you described.